The myogenic response of small arteries to pressure elevation may be mediated by stretch-dependent ion channels and modulated by the autonomic nervous system.
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Animal data implicate stretch channels and alpha-adrenergic modulation in arteriolar myogenic tone; leaves open translation to human hypertension or therapy.
New experimental evidence from in vitro studies supports the concept that small arterial vessels and arterioles constrict in response to intravascular pressure elevation (myogenic response). A stretch-dependent ion channel may be involved. In vivo studies show that stimulation of α-adrenergic receptors enhances the response, suggesting that the myogenic mechanism may be partly under autonomic control.
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Paul C. Johnson (1991) studied this question.
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