May 1, 1999AJP Regulatory Integrative and Comparative Physiology

Resonance in the renal vasculature evoked by activation of the sympathetic nerves

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Population

Anesthetized rabbits

Comparison

Renal nerve stimulation using modulated sine… vs Different frequencies of stimulation and…

Design

Preclinical

Authors

SMSimon C. MalpasUniversity of Auckland THTodd HoreChristchurch Hospital MNMichael NavakatikyanThe University of Sydney

Discussion

Member takes

Implication

Renal sympathetic resonance may stabilize glomerular filtration; leaves open translation of this low-pass mechanism to human hypertension or CKD therapies.

Structured PICO

Population

Anesthetized rabbits

Intervention

Renal nerve stimulation using modulated sine patterns (base frequency 5 Hz, 5-ms duration pulses, amplitude 0-10 V, frequency 0.04-1.0 Hz) with or without endogenous nitric oxide blockade by L-NAME (20 mg/kg)

Comparator

Different frequencies of stimulation and baseline resting state

Outcome

Strength of induced oscillations in renal blood flow (RBF) calculated using spectral analysissurrogate

Sympathetic nerve activity induces resonant oscillations in the renal vasculature, demonstrating a low-pass filtering characteristic that may help maintain stable glomerular filtration.

Cite This Study

Malpas et al. (1999) studied this question.

synapsesocial.com/papers/6a89197746f665d0987609dd https://doi.org/10.1152/ajpregu.1999.276.5.r1311

View Full Paper

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Implication

Renal sympathetic resonance may stabilize glomerular filtration; leaves open translation of this low-pass mechanism to human hypertension or CKD therapies.

Resonance in the renal vasculature evoked by activation of the sympathetic nerves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Resonance in the renal vasculature evoked by activation of the sympathetic nerves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider