Why the study?
Does the efficacy of warfarin prophylaxis against deep vein thrombosis differ between patients undergoing total knee arthroplasty versus total hip arthroplasty?
Does the efficacy of warfarin prophylaxis against deep vein thrombosis differ between patients undergoing total knee arthroplasty versus total hip arthroplasty?
Warfarin prophylaxis is less effective at preventing DVT following total knee arthroplasty compared to total hip arthroplasty, indicating a need for alternative or combined prophylactic methods in TKA.
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Warfarin may be less effective for DVT prevention in TKA than THA; hypothesis-generating and should not yet change practice.
The purpose of this retrospective study was to determine the efficacy of warfarin prophylaxis against deep vein thrombosis (DVT) in total hip arthroplasty (THA) vs total knee arthroplasty (TKA). A review of venograms in 223 patients with THA and in 189 cases of TKA was carried out. The overall DVT rate in THA was 22%. The overall DVT rate in TKA was 46%. We conclude that combined or alternate methods need to be used to decrease the rate of DVT following TKA to that of THA.
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Alexander et al. (1997) studied this question.
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