Why the study?
Does warfarin prophylaxis prevent deep vein thrombosis and pulmonary embolism in patients following total hip and knee arthroplasty?
Does warfarin prophylaxis prevent deep vein thrombosis and pulmonary embolism in patients following total hip and knee arthroplasty?
Warfarin remains a common and effective choice for VTE prophylaxis after THA/TKA, despite the need for frequent monitoring and the occurrence of asymptomatic thrombi.
Warfarin may remain an option for VTE prophylaxis after THA/TKA; leaves open optimal regimens and comparisons amid monitoring burden and asymptomatic thrombi.
Total hip and knee arthroplasty (THA/TKA) are extremely successful procedures that enhance the quality of life of patients with arthritis. However, there remains a significant risk of morbidity and mortality from the development of venous thromboembolic disease (VTE) after these procedures. Despite numerous well-designed clinical trials that have examined the safety and efficacy of prophylaxis following lower extremity joint replacement, the ideal method is yet to be determined. Warfarin prophylaxis has been successfully used to prevent deep vein thrombosis (DVT) and pulmonary embolism (PE) after THA and TKA, and remains the most common choice among orthopaedic surgeons after TKA and THA. High rates of asymptomatic thrombi have been reported in clinical trials, and frequent monitoring is necessary in the postoperative period. This article reviews the efficacy of warfarin prophylaxis and the advantages and disadvantages of oral anticoagulation for patients after THA and TKA.
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Feeley et al. (2004) studied this question.
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