Population
High-conductance calcium-activated potassium (maxi-K) channels and variants of Charybdotoxin (ChTX)
Comparison
Cross-linking of ChTX mutants to maxi-K channels vs Native ChTX
Design
Preclinical
Authors
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Refines maxi-K channel topology mapping; leaves open clinical translation or therapeutic targeting pending mammalian validation.
Identification of Lys32 in charybdotoxin as the residue that cross-links to the beta subunit of maxi-K channels helps define the structural topology of the channel complex.
Munujos et al. (1995) studied this question.
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