Population
COS-1 cells transiently expressing either alpha or alpha + beta subunits of the high-conductance…
Comparison
Coexpression of the beta subunit with the alpha… vs Expression of the alpha subunit alone
Design
Preclinical
Authors
Loading...
Hypothesis-generating for beta subunit modulation of maxi-K channels; leaves open translation to human cardiovascular therapeutics.
The beta subunit of the maxi-K channel significantly enhances the binding affinity of charybdotoxin by affecting both association and dissociation kinetics, suggesting its extracellular loop is in close proximity to the pore.
Hanner et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: