Population
Rat liver tissue, HTC rat hepatoma cells, and human embryonic kidney (HEK-293) cells
Comparison
Cloning and functional expression of a liver… vs Rat brain SK3 (for sequence comparison)
Design
Preclinical
Authors
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May inform hepatobiliary K+ handling in stress; leaves open SK3 as a therapeutic target pending in vivo validation.
The identification and characterization of a liver isoform of SK3 suggests these channels may influence membrane K+ permeability in hepatobiliary cells during metabolic stress or liver injury.
Barfod et al. (2001) studied this question.
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