Why the study?
Cardiac remodeling is linked to inflammation and apoptosis, and the natural flavonol galangin can regulate both processes.
Does galangin prevent cardiac remodeling in preclinical models of pressure overload and angiotensin II stimulation?
Population
Mice subjected to aortic banding (AB) or Sham surgery and angiotensin II-treated H9c2 cells
Comparison
Galangin treatment vs control
Design
Preclinical animal and in vitro study
Follow-up
4 weeks
Authors
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Galangin merits translational study in remodeling; hypothesis-generating from animal data and should not change practice.
Does galangin prevent cardiac remodeling in preclinical models of pressure overload and angiotensin II stimulation?
Galangin demonstrates protective effects against cardiac remodeling in preclinical models by modulating inflammatory and apoptotic pathways.
Wang et al. (2019) studied this question.
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