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January 1, 2006Endocrine JournalOpen Access

Signaling Crosstalk Angiotensin II Receptor Subtypes and Insulin

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Authors

MHMasatsugu HoriuchiGeneral CardiologyMMMasaki MogiEhime UniversityMIMasaru IwaiKumamoto University

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Implication

Supports mechanistic rationale for ARBs in insulin-resistant states; hypothesis-generating and should not yet change practice.

Structured PICO

I
Intervention
Angiotensin II receptor blockers (ARBs)

Understanding the crosstalk between Angiotensin II and insulin signaling provides mechanistic insights into how ARBs may prevent new-onset diabetes and cardiovascular events in insulin-resistant states.

Cite This Study

Horiuchi et al. (2006) studied this question.

synapsesocial.com/papers/6a8920b3789d3eba981a3145https://doi.org/10.1507/endocrj.53.1

Topics

Hypertension management
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Also Consider

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  2. 2Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.1997 · 426 citations
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  5. 5Long-term treatment with losartan versus atenolol improves insulin sensitivity in hypertension: ICARUS, a LIFE substudy2005 · 55 citations