Identification of IEX-1 as a Biomechanically Controlled Nuclear Factor-κB Target Gene That Inhibits Cardiomyocyte Hypertrophy
Population
In vivo murine model of pressure overload and in vitro model of mechanical stimulation of primary…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not inform clinical hypertrophy management; leaves open iex-1 as antihypertrophic target pending in vivo validation.
Structured PICO
P
Population
In vivo murine model of pressure overload and in vitro model of mechanical stimulation of primary cardiomyocytes
I
Intervention
Overexpression of wild-type iex-1 via replication-defective adenoviral gene transfer
O
Outcome
Cardiomyocyte hypertrophy and cell viabilitysurrogate
iex-1 is identified as a biomechanically induced, NF-kappaB-dependent gene that negatively regulates cardiomyocyte hypertrophy.
Cite This Study
Keulenaer et al. (2002) studied this question.