Why the study?
Surgical site infections represent a major component of nosocomial infections, and routine antibacterial prophylaxis is utilized in cardiac surgery to reduce surgical site infections, mortality, and healthcare costs.
Does antimicrobial prophylaxis, specifically first generation cephalosporins or glycopeptides, prevent surgical site infections in adult cardiac surgery?
Does antimicrobial prophylaxis, specifically first generation cephalosporins or glycopeptides, prevent surgical site infections in adult cardiac surgery?
First-generation cephalosporins are as effective as later generations for surgical site infection prophylaxis in adult cardiac surgery, and dosage correction by body weight and renal function can further improve outcomes.
Should not yet change prophylaxis choices in cardiac surgery; leaves open need for randomized confirmation of equivalence.
Surgical site infections comprise a significant part of nosocomial infections. Routine antibacterial prophylaxis is used in cardiac surgery to minimize the incidence of surgical site infections, mortality and treatment cost. We analyzed literature data devoted to this issue. First generation cephalosporins have the same effectiveness as the second and third generation ones. Glycopeptides can be considered as a reasonable alternative with similar safety profile or can be used in combined scheme. Correction of antibiotic dosage by body weight and creatinine clearance can improve the results of antibacterial prophylaxis. Compliance with pharmacological and non-pharmacological protocols is essential for prevention of surgical site infections.
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A.V. Stepin (2023) studied this question.
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