Why the study?
Does 20 min of intermittent hypoxic apneas alter chemoreflex control of muscle sympathetic nerve activity in humans?
Population
21 human subjects
Comparison
Hypoxic apnea vs Hypercapnic hypoxia and isocapnic hypoxia
Design
RCT, Randomly assigned to one of three groups
Follow-up
180 minutes of recovery
Authors
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Acute intermittent hypoxia alters chemoreflex MSNA control with prolonged augmentation; extends causal mechanistic evidence linking OSA to hypertension risk.
Does 20 min of intermittent hypoxic apneas alter chemoreflex control of muscle sympathetic nerve activity in humans?
Short-term exposure to intermittent hypoxia alters chemoreflex control of sympathetic nerve activity, providing mechanistic insight into how obstructive sleep apnea may contribute to the development of hypertension.
Cutler et al. (2004) studied this question.
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