What question did this study set out to answer?

To evaluate the contribution of platelet activation relative to coagulation system enhancement within three days of acute cardioembolic stroke onset in patients with nonvalvular atrial fibrillation.

August 1, 1995Stroke

Platelet Activation Is Not Involved in Acceleration of the Coagulation System in Acute Cardioembolic Stroke With Nonvalvular Atrial Fibrillation

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Why the study?

Is platelet activation involved in the acceleration of the coagulation system in acute cardioembolic stroke with nonvalvular atrial fibrillation?

Population

17 elderly patients with acute cardioembolic stroke due to nonvalvular atrial fibrillation, and 19 healthy…

Design

Case-control

Authors

TNTakehiko NagaoNippon Medical School Musashi Kosugi Hospital MHMakoto HamamotoOtsuka (Japan)AKAkemi KandaJichi Medical University

Discussion

Member takes

Implication

May indicate stasis-driven coagulation over platelet activation in cardioembolic stroke; leaves open targeted antithrombotic strategies in nonvalvular AF.

Key Points

To evaluate the contribution of platelet activation relative to coagulation system enhancement within three days of acute cardioembolic stroke onset in patients with nonvalvular atrial fibrillation.
Examined 17 elderly patients with acute cardioembolic stroke caused by nonvalvular atrial fibrillation alongside 19 age- and sex-matched healthy controls.
Collected arterial blood within 3 days of stroke onset to analyze platelet markers (beta-thromboglobulin and platelet factor 4) and coagulation indicators (thrombin-antithrombin III complex and D-dimer).
Platelet activation indicators showed no statistically significant differences between stroke patients and controls for beta-thromboglobulin (43.8 vs 31.9 ng/mL) or platelet factor 4 (9.06 vs 5.78 ng/mL).
Coagulation-system markers were significantly higher in stroke patients than controls for thrombin-antithrombin III complex (13.8 vs 3.5 ng/mL, P < .01) and D-dimer (366.3 vs 147.2 ng/mL, P < .01).

Structured PICO

Is platelet activation involved in the acceleration of the coagulation system in acute cardioembolic stroke with nonvalvular atrial fibrillation?

Population

17 elderly patients with acute cardioembolic stroke due to nonvalvular atrial fibrillation, and 19 healthy age- and sex-matched control subjects (total n=36).

Comparator

Healthy age- and sex-matched control subjects

Outcome

Levels of beta-thromboglobulin (BTG), platelet factor 4 (PF4), thrombin-antithrombin III complex (TAT), and D-dimer from arterial blood within 3 days of stroke onsetsurrogate

Enhancement of the coagulation system in acute cardioembolic stroke with nonvalvular atrial fibrillation is driven by stasis-related thrombi formation rather than platelet hyperfunction.

Cite This Study

Nagao et al. (1995) studied this question.

synapsesocial.com/papers/6a8924696fb350aba912746a https://doi.org/10.1161/01.str.26.8.1365

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF

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Implication

May indicate stasis-driven coagulation over platelet activation in cardioembolic stroke; leaves open targeted antithrombotic strategies in nonvalvular AF.

Platelet Activation Is Not Involved in Acceleration of the Coagulation System in Acute Cardioembolic Stroke With Nonvalvular Atrial Fibrillation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Platelet Activation Is Not Involved in Acceleration of the Coagulation System in Acute Cardioembolic Stroke With Nonvalvular Atrial Fibrillation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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