Why the study?
Recent evidence highlighted the participation of TMOD1 in diverse cellular processes, prompting a comprehensive overview of its multifaceted biological roles.
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Design
Review
TMOD1 actin regulation merits cardiac model studies; leaves open therapeutic targeting in cardiovascular disease.
Tropomodulin-1 (TMOD1) is a key regulator of actin filament dynamics that functions as an actin-binding protein. It specifically caps the slow-growing (pointed) ends of actin filaments, and the interaction is further stabilized by tropomyosin (TPM). By modulating actin monomer polymerization and depolymerization, TMOD1 critically controls filament length, thereby maintaining both the stability and plasticity of actin-based structures. Emerging evidence has highlighted the participation of TMOD1 in diverse cellular processes, such as cytoskeletal organization, neurite outgrowth, cell motility, and cancer progression. This review summarizes recent advances in TMOD1 research and offers a comprehensive overview of its multifaceted biological roles and implications for future studies.
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Li et al. (2025) studied this question.
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