Key result
The TMOD1 gene SNP c.816A>G was associated with loin eye muscle area and average back fat, identifying it as a candidate gene for muscle production in pigs.
The TMOD1 SNP c.816A>G is associated with lean meat growth and meat quality traits in pigs, identifying it as a candidate gene for muscle production.
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TMOD1 SNP association with porcine muscle traits is hypothesis-generating; leaves open validation for breeding applications.
Tropomodulin 1 (TMOD1) is a member of the tropomodulin family, which are highly conserved capping proteins of the pointed ends of the erythrocyte membrane and sarcomeric actin filaments. Tropomodulins are involved in the architecture of the sarcomere in muscle cells and the membrane skeleton in nonmuscle cells (COLUCCIO et al. 1994, GREGORIO et al. 1995). TMOD1 is predominantly expressed in vertebrate cardiac muscle and slow twitch muscle fibers, and it binds to one end of tropomyosin (TM) that plays important roles in regulating the function of actin filament (FISCHER et al. 2003, GUNNING et al. 2008). Here we identified a single nucleotide polymorphism (SNP) in the porcine TMOD1 gene and further analyzed the effects of this gene on the lean meat growth, meat quality and other related traits in pigs.
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Wu et al. (2009) studied Lean meat growth and meat quality (n=720). TMOD1 gene SNP c.816A>G vs. Alternative genotypes was evaluated on Loin eye muscle area (LEA) (p=<0.0001). The TMOD1 gene SNP c.816A>G was associated with loin eye muscle area and average back fat, identifying it as a candidate gene for muscle production in pigs.
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