Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 12, 2020Science AdvancesOpen Access

Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle

View Full Paper
Ask AI
Bookmark
Share

Comparison

Nebulin shortened vs lengthened by 115 nm

Authors

BKBalázs KissSemmelweis UniversityJGJochen GohlkeUniversity of ArizonaPTPaola ToninoUniversity of Arizona

Discussion

Loading...

Member takes

Implication

Animal data on muscle-type filament regulation warrant clinical caution; leaves open Lmod2 targeting for human cardiac sarcomere disorders.

Structured PICO

P
Population
fast muscles and slow muscle types
I
Intervention
nebulin shortened or lengthened by 115 nm
O
Outcome
thin-filament lengthsurrogate

Strict length control by nebulin promotes high-speed shortening in fast muscles, while dual-regulation by nebulin and Lmod2 enhances contraction efficiency in slow muscles.

Cite This Study

Kiss et al. (2020) studied this question.

synapsesocial.com/papers/6a8924aaf1df03d55b28bb42https://doi.org/10.1126/sciadv.abc1992
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency2009 · 151 citations
  2. 2Evidence that nebulin is a protein‐ruler in muscle thin filaments1991 · 205 citations
  3. 3Nebulin Interacts with CapZ and Regulates Thin Filament Architecture within the Z-Disc2008 · 92 citations
  4. 4Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function2020 · 7 citations
  5. 5The giant protein titin regulates the length of the striated muscle thick filament2017 · 110 citations