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March 17, 2017International Journal of Research in Medical SciencesOpen Access

Evaluation of granisetron as an antiemetic in patients undergoing abdominal hysterectomy under spinal anaesthesia

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Why the study?

Does granisetron prevent intraoperative and postoperative nausea and vomiting compared to ondansetron in women undergoing abdominal hysterectomy under spinal anaesthesia?

Population

80 ASA grade I and II women undergoing abdominal hysterectomy under spinal anaesthesia

Comparison

Injection granisetron 2 mg 10 minutes prior to… vs Injection ondansetron 4 mg 10 minutes prior to…

Design

Cohort

Follow-up

24 hours post-surgery

Authors

SNSiddharth Uttam NikamPKPrakash Narayan KhandelwalUGUjwala B. Gawali

Discussion

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Member takes

Overview

Suggests granisetron may offer superior antiemetic efficacy over ondansetron during hystere.

Structured PICO

Does granisetron prevent intraoperative and postoperative nausea and vomiting compared to ondansetron in women undergoing abdominal hysterectomy under spinal anaesthesia?

P
Population
80 ASA grade I and II women undergoing abdominal hysterectomy under spinal anaesthesia
I
Intervention
Injection granisetron 2 mg 10 minutes prior to induction of spinal anaesthesia
C
Comparator
Injection ondansetron 4 mg 10 minutes prior to induction of spinal anaesthesia
O
Outcome
Occurrence of nausea, retching or vomiting in intraoperative and postoperative period at 6, 12, 18 and 24 hours' post-surgerypatient reported

Granisetron 2 mg is more effective and has a better safety profile than ondansetron 4 mg for preventing nausea and vomiting in women undergoing abdominal hysterectomy under spinal anesthesia.

Cite This Study

Nikam et al. (2017) studied this question.

synapsesocial.com/papers/6a892707ccf6b39be57b57d3https://doi.org/10.18203/2320-6012.ijrms20170995
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