Granisetron has superior control over postoperative nausea and vomiting than ondansetron in gynecological surgeries: a placebo controlled double-blind clinical study

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Introduction: The aim of the study was to compare the antiemetic effects of intravenous ondansetron 80 mcg/kg and granisetron 40 mcg/kg in a double blind placebo controlled manner for prevention of postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgeries. Methods: Ninety patients (ASA I and II) undergoing gynecological laparoscopic surgeries under general anaesthesia were randomly allocated into three groups; Group A (n=30) received 40mcg/kg granisetron intravenously, group B (n=30) received 80mcg/kg ondansetron intravenously and group C (n=30) received 5 ml of normal saline by the same route 2 minutes before induction of general anaesthesia. Anesthetic procedure was standardized for all patients. Data was collected and analyzed statistically. Results: The incidence of nausea and vomiting over a period of 24 hour were found in 20% of patients who had received granisetron, 45% of patients who had received ondansetron and 77.5% of patients who had received placebo. It was also observed that, 32 patients (80%) of group A and 22 patients (55%) in group B did not experience any nausea and vomiting, whereas only 9 patients (22.5%) of group C did not experience nausea and vomiting. At the same time it was observed that, in group A, 8 patients (20%) had to be administered rescue antiemetics; while in group B, 18 patients (45%) and in group C, 31 patients (77.5%) received antiemetics. Conclusion: It was concluded that granisetron is more effective than ondansetron and placebo in controlling postoperative nausea & vomiting after laparoscopic gynecological surgery.