The Occurrence of Tri-Iodothyronine as the Only Circulating Thyroid Hormone

Case Reports1 August 1959THE OCCURRENCE OF TRI-IODOTHYRONINE AS THE ONLY CIRCULATING THYROID HORMONEJ. J. RUPP, M.D., C. CHAVARRIA, M.D., K. E. PASCHKIS, M.D., EUGENIE CHUBLARIAN, M.D.J. J. RUPP, M.D.Search for more papers by this author, C. CHAVARRIA, M.D.Search for more papers by this author, K. E. PASCHKIS, M.D.Search for more papers by this author, EUGENIE CHUBLARIAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-2-359 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of nontoxic goiter in endemic goiter areas can be attributed to iodine deficiency. However, the etiology of nontoxic goiters in euthyroid people in areas not deficient in iodine remains obscure. Rare causes of goiter in people living in such areas are the ingestion of naturally occurring goitrogens (struma cibaria),1or the use of agents such as sulfonamides, thiocyanate2and resorcinol,3among others. In these instances the responsible agent interferes with iodide metabolism in the thyroid, with a resultant decrease in the production of thyroid hormones. The occurrence of goiter associated with cretinism as an inborn error of metabolism...Bibliography1. FisherEpsteinPaschkis GDKE: Case of struma cibaria, J. Clin. Endocrinol. 12: 1100, 1952. CrossrefGoogle Scholar2. RichardsBrockhurstColeman CERJTH: Thiocyanate goiter with myxedema; 2 cases, J. Clin. Endocrinol. 9: 446, 1949. CrossrefGoogle Scholar3. BullFraser GMR: Myxaedema from resorcinol ointment applied to leg ulcers, Lancet 1: 851, 1950. CrossrefMedlineGoogle Scholar4. StanburyMcGirr JBEM: Sporadic or non-endemic familial cretinism with goiter, Am. J. Med. 22: 712, 1957. CrossrefMedlineGoogle Scholar5. DingledinePitt-RiversStanbury WSRJB: Nature and transport of the iodinated substances of the blood of normal subjects and of patients with thyroid disease, J. Clin. Endocrinol. and Metabolism 15: 724, 1955. CrossrefGoogle Scholar6. Pitt-RiversHubbleHoather RDWH: A chromatographic study of thyroidal iodine metabolism in nontoxic goiter, J. Clin. Endocrinol. and Metabolism 17: 1313, 1957. CrossrefGoogle Scholar7. DiGeorgePaschkis AMKE: Sporadic hypothyroidism associated with goiter, J. Clin. Endocrinol. and Metabolism 17: 645, 1957. CrossrefGoogle Scholar8. RobbinsRallRawson JJERW: A new serum iodine component in patients with functional carcinoma of the thyroid, J. Clin. Endocrinol. and Metabolism 15: 1315, 1955. CrossrefGoogle Scholar9. OwenMcConahey CAWM: An unusual iodinated protein of the serum in Hashimoto's thyroiditis, J. Clin. Endocrinol. and Metabolism 16: 1507, 1956. CrossrefGoogle Scholar10. Wilkinson JH, in Ciba Foundation Colloquia on Endocrinology, Vol. 10, Regulation of mode of action of thyroid hormones, 1957, Little, Brown and Company, Boston, p. 213. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication February 21, 1958.From the Department of Medicine and Division of Endocrine and Cancer Research, Jefferson Medical College, Philadelphia.†Kellogg Fellow. Present address: Hospital infantil, Mexico, D. F.Requests for reprints should be addressed to J. J. Rupp, M.D., Jefferson Medical College, 1025 Walnut Street, Philadelphia, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTRIIODOTHYRONINE THYROTOXICOSISKontrollierte HyperthyreosetherapieProduction of triiodothyronine in normal human subjects and in patients with hyperthyroidismTriiodothyronine HyperthyroidismCLINICAL AND LABORATORY OBSERVATIONS IN CASES OF TRIIODOTHYRONINE TOXICOSIS CONFIRMED BY RADIOIMMUNOASSAYInterpretation of Serum Tri-Iodothyronine Levels Measured by the Sterling TechnicFree Thyroxine and TriiodothyronineThe Significance of Circulating TriiodothyronineThe Diagnostic Value of Protein‐bound Radio‐iodine Estimation in an Endemic Goitre RegionThe changing pattern of circulating iodinated amino acids in a case of thyrotoxicosisAn abnormality of thyroid hormone secretion 1 August 1959Volume 51, Issue 2Page: 359-362KeywordsBlood plasmaEtiologyHormone synthesisInborn errors of metabolismIngestionProteinsSulfonamideThyroidThyroid hormones ePublished: 1 December 2008 Issue Published: 1 August 1959 PDF downloadLoading ...