Why the study?
Does fentanyl pretreatment reduce the thiopentone dose required for induction of anaesthesia in adults?
Does fentanyl pretreatment reduce the thiopentone dose required for induction of anaesthesia in adults?
Pretreatment with fentanyl dose-dependently reduces the thiopentone requirement for induction of anaesthesia without adverse effects.
Fentanyl pretreatment supports lower thiopentone dosing for induction; confirms opioid synergy in this RCT and warrants clinical consideration.
The thiopentone dose needed for satisfactory induction of anaesthesia was determined in 60 adult patients using a double-blinded study design. No premedication was given. The effect of pretreatment with four different doses of fentanyl on ED50 for thiopentone was determined and compared with a control group not receiving fentanyl. The cardiovascular effects of the combinations were also studied. ED50 for thiopentone was reduced from 4.0 mg.kg-1 in the control group to 2.2 mg.kg-1 in patients receiving fentanyl 5.0 micrograms.kg-1. Only in the group of patients receiving fentanyl 5.0 micrograms.kg-1 was there no significant change in systolic arterial blood pressure. An increased heart rate was noted in patients induced with thiopentone in combination with fentanyl 0.625 micrograms.kg-1. No adverse effects of thiopentone, fentanyl or the combinations were noted.
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Wang et al. (1996) studied this question.
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