Why the study?
Does fentanyl reduce the MAC of desflurane in adult patients undergoing anesthesia?
Population
134 adult patients undergoing anesthesia
Comparison
Fentanyl and thiopental at induction, followed… vs Desflurane in oxygen alone
Design
Other
Follow-up
Until awakening from anesthesia
Authors
Loading...
Fentanyl may permit lower desflurane concentrations; extends MAC interaction data but leaves open optimal dosing and safety.
Does fentanyl reduce the MAC of desflurane in adult patients undergoing anesthesia?
A single 3 micrograms/kg dose of fentanyl significantly reduces the MAC of desflurane, with higher doses providing little additional reduction.
Sebel et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: