Key result
Low-dose fentanyl significantly reduced the incidence of tachycardia (5% vs 55%) and tachypnea compared to placebo during sevoflurane induction.
Why the study?
Does low-dose fentanyl improve the quality of sevoflurane induction in healthy adult patients premedicated with midazolam?
Population
104 healthy adult patients (16-55 yr) premedicated with midazolam
Comparison
I.V. fentanyl 0.5/kg before induction with 8… vs Placebo before induction
Design
RCT, randomized, blinded observer
Follow-up
during induction and intubation
Authors
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Supports low-dose fentanyl addition for stable sevoflurane induction in adults; extends co-induction evidence to midazolam-premedicated patients.
RCT (n=40)
Single-blind (observer)
Randomized
No
Does low-dose fentanyl improve the quality of sevoflurane induction in healthy adult patients premedicated with midazolam?
Absolute Event Rate: 5% vs 55%
p-value: p=<0.05
Low-dose fentanyl improves the hemodynamic and respiratory stability of sevoflurane inhalation induction in adults premedicated with midazolam.
Shim et al. (2003) conducted an RCT in Anesthesia induction (n=40). Fentanyl vs. Placebo was evaluated on Incidence of tachycardia during induction (p=<0.05). Low-dose fentanyl significantly reduced the incidence of tachycardia (5% vs 55%) and tachypnea compared to placebo during sevoflurane induction.
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