Key result
Midazolam pretreatment at 30 μg/kg did not significantly reduce the MACBAR of desflurane with an effect-site concentration of remifentanil 1.0 ng/ml compared to saline (6.8% vs 7.1%, P=0.755).
Why the study?
Does midazolam pretreatment reduce the MACBAR of desflurane with remifentanil in patients undergoing thyroidectomy?
RCT (n=65)
Computer-generated random number table
No
Does midazolam pretreatment reduce the MACBAR of desflurane with remifentanil in patients undergoing thyroidectomy?
Midazolam pretreatment does not reduce the desflurane requirement for blunting the sympathetic response to surgical incision when combined with remifentanil.
Answers are grounded in this paper and cite their sources.
Midazolam pretreatment offers no reduction in desflurane MACBAR with remifentanil; confirms lack of benefit for blunting sympathetic responses during thyroidectomy.
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No et al. (2015) conducted an RCT in General anesthesia for thyroidectomy (n=65). Midazolam vs. Isovolemic saline was evaluated on Minimum alveolar concentration blockade of adrenergic responses (MACBAR) of desflurane with 1 ng/ml remifentanil (p=0.755). Midazolam pretreatment at 30 μg/kg did not significantly reduce the MACBAR of desflurane with an effect-site concentration of remifentanil 1.0 ng/ml compared to saline (6.8% vs 7.1%, P=0.755).
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