Key result
A single bolus of 1.0 μg/kg remifentanil significantly increased the proportion of patients maintaining stable mean blood pressure within ± 25% of preinduction values compared to control (53.8% vs 14.8%, p=0.003) during desflurane anesthesia induction.
Why the study?
Does a single bolus of remifentanil prevent adverse hemodynamic responses during induction of anesthesia with desflurane and tracheal intubation in healthy adults?
RCT (n=103)
Double-blind
Computerized randomization table
No
Does a single bolus of remifentanil prevent adverse hemodynamic responses during induction of anesthesia with desflurane and tracheal intubation in healthy adults?
Absolute Event Rate: 53.8% vs 14.8%
p-value: p=0.003
A single bolus of 1.0 μg/kg remifentanil effectively maintains stable blood pressure and attenuates adverse hemodynamic responses during anesthesia induction with desflurane and tracheal intubation.
Supports remifentanil bolus for hemodynamic stability during desflurane induction; extends opioid attenuation evidence to this agent.
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Kang et al. (2015) conducted an RCT in Elective surgery under general anesthesia (n=103). Remifentanil vs. Normal saline was evaluated on Proportion of patients with mean blood pressure maintained within ± 25% of preinduction values (p=0.003). A single bolus of 1.0 μg/kg remifentanil significantly increased the proportion of patients maintaining stable mean blood pressure within ± 25% of preinduction values compared to control (53.8% vs 14.8%, p=0.003) during desflurane anesthesia induction.
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