Key result
Bolus administration of 1 microg/kg remifentanil over 1 to 5 minutes caused severe hemodynamic instability in 4 of 8 patients, leading to early study termination.
Why the study?
Does bolus administration of remifentanil cause hemodynamic instability in patients scheduled for coronary artery bypass grafting?
Population
8 patients scheduled for coronary artery bypass grafting anesthetized with small-dose propofol
Comparison
Bolus administration of 1 microg/kg remifentanil… vs Different rates of remifentanil administration
Design
Cohort
Authors
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May be associated with severe hemodynamic instability in CABG patients; leaves open optimal administration rates for randomized confirmation.
Does bolus administration of remifentanil cause hemodynamic instability in patients scheduled for coronary artery bypass grafting?
Bolus administration of remifentanil in patients undergoing coronary artery bypass grafting causes severe hemodynamic instability and should only be given by slow infusion.
Elliott et al. (2000) studied Coronary artery disease (n=8). Remifentanil vs. Different infusion rates was evaluated on Hemodynamic instability. Bolus administration of 1 microg/kg remifentanil over 1 to 5 minutes caused severe hemodynamic instability in 4 of 8 patients, leading to early study termination.
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