Key result
Large-dose remifentanil reduced mean cerebral blood flow velocity by 31% compared to no change with moderate-dose remifentanil in patients undergoing CABG surgery (P<0.05).
Why the study?
Does large-dose remifentanil reduce cerebral blood flow velocity compared to moderate-dose remifentanil in patients undergoing elective coronary artery bypass graft surgery?
Population
20 patients (ASA physical status III) scheduled for elective coronary artery bypass graft surgery
Comparison
Remifentanil 5 µg/kg IV induction maintained… vs Remifentanil 2 µg/kg IV induction maintained…
Design
Other
Follow-up
10 minutes
Authors
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May warrant caution with large-dose remifentanil in CABG; leaves open effects on neurologic outcomes pending randomized data.
Does large-dose remifentanil reduce cerebral blood flow velocity compared to moderate-dose remifentanil in patients undergoing elective coronary artery bypass graft surgery?
Effect estimate: 31% decrease
p-value: p=<0.05
Large-dose, but not moderate-dose, remifentanil reduces cerebral blood flow velocity independent of systemic hemodynamics in isocapnic cardiac patients.
Paris et al. (1998) studied Coronary artery disease requiring bypass graft surgery (n=20). Remifentanil vs. Moderate-dose remifentanil (2 µg/kg IV induction, 1 µg/kg/min maintenance) was evaluated on Mean cerebral blood flow velocity (Vmean) (31% decrease, p=<0.05). Large-dose remifentanil reduced mean cerebral blood flow velocity by 31% compared to no change with moderate-dose remifentanil in patients undergoing CABG surgery (P<0.05).
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