Key result
Bolus administration of 1 μg/kg remifentanil caused severe hemodynamic instability in 4 of 8 patients undergoing coronary artery bypass grafting, prompting early study termination.
Why the study?
Does bolus administration of remifentanil cause severe hemodynamic depression in patients with coronary artery disease undergoing CABG?
Population
n=8 patients with coronary artery disease scheduled for coronary artery bypass grafting, anesthetized with…
Comparison
Bolus administration of 1 μg/kg remifentanil for… vs Different rates of remifentanil administration
Design
Case_series
Authors
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May warrant caution with bolus remifentanil in CABG; hypothesis-generating and requires prospective trials before practice change.
Does bolus administration of remifentanil cause severe hemodynamic depression in patients with coronary artery disease undergoing CABG?
Bolus administration of remifentanil causes severe cardiovascular depression in patients with coronary artery disease undergoing CABG and should only be given by slow infusion.
Elliott et al. (2000) studied Coronary artery disease (n=8). Remifentanil vs. Different infusion rates was evaluated on Hemodynamic effects. Bolus administration of 1 μg/kg remifentanil caused severe hemodynamic instability in 4 of 8 patients undergoing coronary artery bypass grafting, prompting early study termination.
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