Key result
Remifentanil 1 µg/kg reduces SBP ~6 mmHg and pulse rate vs 0.5 µg/kg during anesthesia induction.
Why the study?
Endotracheal intubation causes hemodynamic spikes, and various doses of remifentanil have been used to prevent these responses without consensus on optimal dosing.
Does a 1 µg/kg dose of intravenous remifentanil reduce the cardiovascular response to endotracheal intubation compared to a 0.5 µg/kg dose in patients undergoing elective surgery?
RCT (n=35)
Double-blind
Randomly assigned
No
Does a 1 µg/kg dose of intravenous remifentanil reduce the cardiovascular response to endotracheal intubation compared to a 0.5 µg/kg dose in patients undergoing elective surgery?
Absolute Event Rate: 107.83% vs 113.35%
p-value: p=0.008
An induction dose of 1 µg/kg remifentanil is more effective than 0.5 µg/kg at attenuating the hemodynamic spikes associated with endotracheal intubation.
No takes yet. Share an insight, caveat, or question.
1 µg/kg remifentanil attenuates intubation-induced hypertension more than 0.5 µg/kg; extends RCT evidence for optimal dosing during induction.
Suwarman et al. (2022) conducted an RCT in Elective surgery under general anesthesia (n=35). Remifentanil vs. Remifentanil 0.5 µg/kg bolus followed by 0.1 µg/kg/min infusion was evaluated on Systolic blood pressure after induction (p=0.008). Administration of 1 µg/kg remifentanil significantly reduced systolic blood pressure (107.83 vs 113.35 mmHg, p=0.008) and pulse rate compared to 0.5 µg/kg during induction of anesthesia.
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