Key result
A 1.0 microgram/kg bolus of remifentanil significantly attenuated the increase in heart rate and systolic arterial pressure following tracheal intubation compared to placebo (p < 0.01).
Why the study?
Does remifentanil reduce the haemodynamic response to laryngoscopy and tracheal intubation in ASA 1 or 2 patients presenting for elective surgery?
RCT (n=80)
Double-blind
random allocation
Does remifentanil reduce the haemodynamic response to laryngoscopy and tracheal intubation in ASA 1 or 2 patients presenting for elective surgery?
p-value: p=< 0.01
A 1.0 microgram.kg-1 bolus of remifentanil significantly attenuates the haemodynamic response to tracheal intubation compared to placebo.
Supports remifentanil 1 μg/kg bolus to blunt intubation haemodynamics in elective ASA 1-2 patients; confirms efficacy versus placebo.
We have studied the effect of three bolus doses of remifentanil on the haemodynamic response to laryngoscopy and tracheal intubation. Using a double-blind design, 80 ASA 1 or 2 patients presenting for elective surgery received saline placebo or remifentanil 0.25, 0.5 or 1.0 microgram.kg-1 by random allocation. Anaesthesia was induced with thiopentone 5-7 mg.kg-1 and followed immediately by the study medication given as a bolus over 30s. Muscle relaxation was provided with rocuronium 0.75 mg.kg-1. The patients' tracheas were intubated under direct laryngoscopy 1 min later. Noninvasive arterial blood pressure and heart rate were recorded immediately before induction of anaesthesia and then at intervals until 5 min after tracheal intubation. There was a significant increase in heart rate (p < 0.01) and systolic arterial pressure (p < 0.01) in all groups after tracheal intubation. However, this was short-lived and of a smaller magnitude in the remifentanil 1 microgram.kg-1 group in which the increase was significantly lower than in the control group (p < 0.01).
No takes yet. Share an insight, caveat, or question.
McAtamney et al. (1998) conducted an RCT in Elective surgery (n=80). Remifentanil vs. Saline placebo was evaluated on Haemodynamic response (heart rate and systolic arterial pressure) to laryngoscopy and tracheal intubation (p=< 0.01). A 1.0 microgram/kg bolus of remifentanil significantly attenuated the increase in heart rate and systolic arterial pressure following tracheal intubation compared to placebo (p < 0.01).
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: