What question did this study set out to answer?

The study aimed to compare the time of emergence from anesthesia between desflurane and isoflurane in surgical patients.

March 1, 1991AnesthesiologyOpen Access

Desflurane and Isoflurane in Surgical Patients

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Why the study?

Does desflurane reduce emergence time compared to isoflurane in patients undergoing elective surgery?

Population

28 patients undergoing elective surgery

Comparison

Desflurane with sodium thiopental induction and… vs Isoflurane with sodium thiopental induction and…

Design

RCT, randomly divided into four groups

Follow-up

Immediate post-anesthesia

Authors

RSRichard M. SmileyColumbia University EOEugene OrnsteinColumbia University RMRichard S. MatteoNorthwestern University

Discussion

Member takes

Implication

Clinicians may select desflurane to expedite emergence in elective cases; this RCT extends comparative data on volatile anesthetics.

Key Points

The study aimed to compare the time of emergence from anesthesia between desflurane and isoflurane in surgical patients.
Randomized, controlled trial involving 28 patients divided into four groups based on anesthesia agent and dosage.
Anesthesia was induced with sodium thiopental and supplemented with N2O 60%.
Emergence time recorded as the time taken for patients to respond after discontinuation of anesthetic gases.
Patients receiving desflurane 0.65 MAC had an emergence time of 8.8 +/- 2.7 min compared to 15.6 +/- 4.3 min for isoflurane 0.65 MAC (P < 0.01).
Emergence time for desflurane 1.25 MAC was 16.1 +/- 6.0 min vs. isoflurane 1.25 MAC at 30.0 +/- 11.0 min (P < 0.05).
Desflurane anesthesia resulted in a significantly quicker emergence than isoflurane at both dosages.

Structured PICO

Does desflurane reduce emergence time compared to isoflurane in patients undergoing elective surgery?

Population

28 patients undergoing elective surgery

Intervention

Desflurane (0.65 MAC or 1.25 MAC) with sodium thiopental induction and N2O 60%

Comparator

Isoflurane (0.65 MAC or 1.25 MAC) with sodium thiopental induction and N2O 60%

Outcome

Emergence time (time from discontinuation of anesthetic gases until patients opened their eyes and squeezed the investigator's hand in response to a command)

Desflurane provides a more rapid emergence from anesthesia compared to isoflurane in surgical patients.

Cite This Study

Smiley et al. (1991) studied this question.

synapsesocial.com/papers/6a706b7935aa2c282ce1bce9 https://doi.org/10.1097/00000542-199103000-00006

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Desflurane and Isoflurane in Surgical Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Desflurane and Isoflurane in Surgical Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider