Why the study?
The authors aimed to evaluate the clinical characteristics and outcomes of patients admitted with acute pulmonary embolism at a single center over a 5-year period.
Does systemic thrombolysis improve outcomes or increase bleeding in patients with acute pulmonary embolism?
Population
114 patients admitted with acute PE
Comparison
Thrombolysis vs nonthrombolysis, and central PE vs peripheral PE
Design
Single-center retrospective study
Follow-up
90 days
Authors
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Thrombolysis was associated with higher bleeding despite pulmonary hypertension improvement in acute PE; leaves open net clinical benefit pending randomized trials.
Does systemic thrombolysis improve outcomes or increase bleeding in patients with acute pulmonary embolism?
Non-guideline use of systemic thrombolysis in acute pulmonary embolism is associated with significantly increased bleeding risk despite improvements in pulmonary hypertension.
Showkathali et al. (2021) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: