Prevention of AMI Induced Ventricular Remodeling: Inhibitory Effects of Heart‐Protecting Musk Pill on IL‐6 and TNF‐Alpha

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Why the study?

Does Heart-Protecting Musk Pill reduce inflammatory cytokines and ameliorate ventricular remodeling in rats with acute myocardial infarction?

Population

Sprague-Dawley (SD) rats with acute myocardial infarction (AMI) induced by coronary artery ligation

Design

Preclinical

Authors

Discussion

Supports HMP investigation in AMI; hypothesis-generating from rat data only.

Does Heart-Protecting Musk Pill reduce inflammatory cytokines and ameliorate ventricular remodeling in rats with acute myocardial infarction?

Population

Sprague-Dawley (SD) rats with acute myocardial infarction (AMI) induced by coronary artery ligation

Intervention

Heart-Protecting Musk Pill (HMP)

Outcome

Concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and ventricular remodelingsurrogate

In a rat model of AMI, Heart-Protecting Musk Pill reduced inflammatory cytokines and ameliorated ventricular remodeling.

Cen et al. (2017) studied this question.

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