This case provides histological evidence that myocardial ischemia without reperfusion can induce apoptosis in cardiomyocytes.
Single-case finding precludes practice change; leaves open apoptosis as contributor to postinfarction rupture.
Recent studies have reported that apoptosis may be induced by reperfusion injury following ischemia in cardiomyocytes. We present a case with evidence of apoptosis induced by myocardial ischemia without reperfusion. DNA fragmentation was demonstrated in the nuclei of the myocardial cells surrounding the ventricular septal rupture following acute myocardial infarction without reperfusion in the infarct-related left anterior descending coronary artery. This finding suggests that ischemia without reperfusion may induce apoptosis in myocardial cells.
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Toyoda et al. (1998) studied this question.
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