Why the study?
Do modifications at the C6 position of the K(ATP) opener BMS-180448 improve cardioprotective potency and cardiac selectivity in globally ischemic rat hearts?
Do modifications at the C6 position of the K(ATP) opener BMS-180448 improve cardioprotective potency and cardiac selectivity in globally ischemic rat hearts?
Modifications at the C6 position of BMS-180448 yield highly potent and cardiac-selective K(ATP) openers, supporting distinct structure-activity relationships for cardioprotective versus vasorelaxant properties.
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Yields potent cardiac-selective K(ATP) openers; leaves open translation to clinical ischemia.
Ding et al. (1999) studied this question.
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