Key result
BMS-180448 provided cardioprotection similar to cromakalim (EC25 3.3 vs 3.2 microM) without causing action potential duration shortening, and both effects were abolished by glyburide.
The cardioprotective effect of the KATP opener BMS-180448 is independent of action potential shortening and is not associated with sarcolemmal KATP opening, suggesting a potential for reduced proarrhythmic activity.
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May reduce proarrhythmic concerns with KATP openers in ischemia models; leaves open clinical translation.
Grover et al. (1995) studied Ischemic myocardium. BMS-180448 vs. Cromakalim was evaluated on Action potential duration (APD) shortening and cardioprotective activity (time to onset of contracture). BMS-180448 provided cardioprotection similar to cromakalim (EC25 3.3 vs 3.2 microM) without causing action potential duration shortening, and both effects were abolished by glyburide.
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