Kinetics of uptake of 2‐deoxy‐d‐glucose and 2‐aminoisobutyric acid in chemically transformed cells

Kinetics of 2‐deoxy‐D‐glucose and 2‐aminoisobutyric acid uptake in chemically transformed hamster embryo cells and BALB 3T3 cells were investigated. Maximum velocity of the glucose uptake in chemically transformed cells increased 1.5 to 2.8‐fold over controls in Vmax without a detectable change in apparent Km. In uptake of the amino acid there was a slight change in Vmax and unchanged Km with chemically transformed cells, as compared to untransformed cells. Hexokinase activity showed a slight change after chemical transformation.