Why the study?
Do AT1 and AT2 receptors mediate Angiotensin II-induced facilitation of noradrenaline release in human atrial tissue?
Population
Human atrial appendages prelabeled with [3H]-noradrenaline
Comparison
Angiotensin I and II, with or without… vs Control conditions and tissues from patients not…
Design
Preclinical
Authors
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Supports dual AT1/AT2 roles in cardiac sympathetic facilitation; leaves open human atrial translation and ACE inhibitor interactions.
Do AT1 and AT2 receptors mediate Angiotensin II-induced facilitation of noradrenaline release in human atrial tissue?
Both AT1 and AT2 receptors contribute to Angiotensin II-mediated facilitation of sympathetic neurotransmission in the human heart, which may be upregulated by chronic ACE inhibitor therapy.
Muayed et al. (2004) studied this question.
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