June 1, 2002Journal of Hypertension

Comparison of the vascular and antiadrenergic activities of four angiotensin II type 1 antagonists in the pithed rat

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Population

Pithed, spontaneously hypertensive rats

Design

Preclinical

Authors

ADAndreas DendorferCentre of Experimental Medicine of the Slovak Academy of Sciences WRWalter RaaschUniversity Hospital Schleswig-Holstein KTKlaus TempelBristol-Myers Squibb (Germany)

Discussion

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Implication

No evidence for tissue-specific AT1 subtypes in this model; leaves open relevance to human therapy.

Structured PICO

Population

Pithed, spontaneously hypertensive rats

Intervention

Cumulatively increasing doses of AT1 antagonists (candesartan, eprosartan, EXP 3174, and irbesartan) prior to intravenous angiotensin II or noradrenaline

Outcome

Angiotensin II-induced catecholamine release (measured by plasma noradrenaline) and vasoconstriction (measured by acute increases in blood pressure)surrogate

AT1 antagonists do not discriminate between presynaptic neuronal and postsynaptic vascular angiotensin II receptors, refuting the existence of tissue-specific AT1 receptor subtypes.

Cite This Study

Dendorfer et al. (2002) studied this question.

synapsesocial.com/papers/6a7c7f4592ac09e93f8f13cb https://doi.org/10.1097/00004872-200206000-00027

View Full Paper

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Comparison of the vascular and antiadrenergic activities of four angiotensin II type 1 antagonists in the pithed rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of the vascular and antiadrenergic activities of four angiotensin II type 1 antagonists in the pithed rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider