Key result
In the pithed rat model, AT1 receptor blockers and ACE inhibitors dose-dependently reduced the stimulation-induced rise in diastolic blood pressure, with telmisartan being the most potent AT1 blocker.
Population
Male, normotensive pithed rat model
Comparison
Losartan, irbesartan, telmisartan and captopril vs Comparison between different agents and doses…
Design
Preclinical
Authors
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Hypothesis-generating for differential ARB potency; human trials needed before any clinical implications.
In a pithed rat model, AT1 receptor blockers and ACE inhibitors dose-dependently reduce sympathetic neurotransmission-induced blood pressure increases, with telmisartan showing the highest potency among AT1 blockers.
Balt et al. (2001) studied normotensive pithed rat model. AT1 receptor blockers (losartan, irbesartan, telmisartan) and ACE inhibitor (captopril) was evaluated on Rise in diastolic blood pressure (DBP) upon electrical stimulation of the thoraco-lumbar spinal cord. In the pithed rat model, AT1 receptor blockers and ACE inhibitors dose-dependently reduced the stimulation-induced rise in diastolic blood pressure, with telmisartan being the most potent AT1 blocker.
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