Key result
In the pithed rat, eprosartan was the most potent sympathoinhibitory agent, while candesartan was the most potent inhibitor of direct Ang II pressor effects (P<0.05 for both comparisons).
Population
Pithed rat model
Comparison
AT1 receptor blockers vs Comparison among the four AT1 receptor blockers
Design
Preclinical
Authors
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Should not guide ARB selection in patients; leaves open differential presynaptic AT1 effects for human study.
p-value: p=< 0.05
Different AT1 receptor blockers exhibit varying affinities for pre- and postsynaptic AT1 receptors in the pithed rat model, with eprosartan showing the highest sympathoinhibitory potency and candesartan the highest postsynaptic inhibitory potency.
Balt et al. (2001) studied this question. valsartan, candesartan, eprosartan and embusartan was evaluated on sympathoinhibitory potencies (ED20 values) and inhibition of Ang II-induced increase in DBP (pA2 values) (p=< 0.05). In the pithed rat, eprosartan was the most potent sympathoinhibitory agent, while candesartan was the most potent inhibitor of direct Ang II pressor effects (P<0.05 for both comparisons).
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