Key result
Eprosartan (0.3 mg/kg i.v.) inhibited the pressor response induced by spinal cord stimulation in pithed rats, whereas equivalent doses of losartan, valsartan, and irbesartan had no effect.
Why the study?
Does eprosartan inhibit sympathetic outflow compared to other angiotensin II receptor antagonists in pithed rats?
Population
Pithed rats
Comparison
Eprosartan (0.3 mg/kg i.v.) vs Equivalent doses of other nonpeptide angiotensin…
Design
Preclinical
Authors
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May attenuate prejunctional sympathetic facilitation in models; leaves open clinical sympatholytic effects of ARBs beyond AT1 blockade.
Does eprosartan inhibit sympathetic outflow compared to other angiotensin II receptor antagonists in pithed rats?
Eprosartan uniquely inhibits sympathetic outflow in a rat model compared to other ARBs, suggesting a potential mechanism for greater efficacy in treating isolated systolic hypertension.
Ohlstein et al. (2008) studied this question. Eprosartan vs. Losartan, valsartan, and irbesartan was evaluated on Pressor response induced by spinal cord stimulation. Eprosartan (0.3 mg/kg i.v.) inhibited the pressor response induced by spinal cord stimulation in pithed rats, whereas equivalent doses of losartan, valsartan, and irbesartan had no effect.
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