Population
Pithed rat model
Comparison
Losartan and captopril, alone or in combination… vs Baseline (before administration)
Design
Preclinical
Authors
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No clinical implications from this animal study; hypothesis-generating for captopril's bradykinin-NO effects on vascular reactivity.
Losartan and captopril both decrease pressor responses to sympathetic nerve stimulation by inhibiting noradrenaline release, but captopril uniquely decreases vascular reactivity to noradrenaline via a bradykinin/nitric oxide-dependent mechanism.
Yokoyama et al. (1997) studied this question.
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