Why the study?
Does close loop stimulation (CLS) pacing improve cardiovascular response to standing compared to fixed pacing rate (DDD) in patients with pacemakers for sinus node disease and AV block?
Population
5 patients with a pacemaker (CLS-INOS(2)) for sinus node disease and atrio-ventricular block
Comparison
Close loop stimulation pacing mode allowing… vs Fixed pacing rate mode during a 5-minute tilt test
Design
RCT, Random order of tilt tests
Follow-up
5 minutes (duration of tilt test)
Authors
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CLS pacing confers no postural hemodynamic benefit over DDD; challenges presumed advantage of rate-adaptive CLS in sinus node disease.
Does close loop stimulation (CLS) pacing improve cardiovascular response to standing compared to fixed pacing rate (DDD) in patients with pacemakers for sinus node disease and AV block?
Upright rate-rise pacing (CLS mode) does not improve systolic blood pressure or cardiac output during standing and may worsen the blood pressure response compared to fixed rate pacing.
Fortrat et al. (2005) studied this question.
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