December 1, 1993Endocrinology

Identification and characterization of angiotensin-II receptor subtypes in cultured bovine and human adrenal fasciculata cells and PC12W cells.

View Full Paper

Ask AI

Bookmark

Population

Cultured bovine adrenal cells, human adrenal fasciculata-reticularis cells, COS-7 cells transfected with…

Design

Preclinical

Authors

ROR. OualiHopital Universitaire Hedi Chaker MLM C LebrethonCentre Hospitalier Universitaire de Liège JSJ.M. SaezUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

Distinguishes AT1/AT2 subtypes molecularly in cell models; leaves open translation to human cardiovascular applications.

Structured PICO

Population

Cultured bovine adrenal cells (BAC), human adrenal fasciculata-reticularis cells, COS-7 cells transfected with human AT1 cDNA, and PC12W cells

Intervention

Binding and cross-linking experiments using [125I]Ang II and [125I]CGP42112, with antagonists losartan and CGP42112

Outcome

Molecular weight (Mr) of AT1 and AT2 receptor subtypessurrogate

The study demonstrates that the AT1 and AT2 receptor subtypes have distinct molecular weights (50,000 and 70,000, respectively), explaining previously reported size heterogeneity.

Cite This Study

Ouali et al. (1993) studied this question.

synapsesocial.com/papers/6a89325546f665d09876137d https://doi.org/10.1210/endo.133.6.8243303

View Full Paper

Ask AI

Bookmark

Identification and characterization of angiotensin-II receptor subtypes in cultured bovine and human adrenal fasciculata cells and PC12W cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification and characterization of angiotensin-II receptor subtypes in cultured bovine and human adrenal fasciculata cells and PC12W cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider