Population
Adult mammalian hearts and fetal/neonatal rats, rabbits, cats, and dogs
Design
Preclinical
Authors
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Species differences in myocyte nucleation urge caution extrapolating animal models to humans; leaves open mechanisms of human cardiomyocyte turnover.
Unlike many other mammalian species which exhibit high rates of binucleation, adult human cardiac myocytes are predominantly mononucleated.
Korecký et al. (1979) studied this question.
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