Why the study?
Does bosentan reduce renal vascular fibrosis and improve survival in L-NAME-induced hypertensive mice?
Population
Transgenic mice harboring the luciferase gene under the control of the collagen I-alpha2 chain promoter…
Comparison
Bosentan coadministered with L-NAME for 10 weeks. vs Continued L-NAME alone for 10 weeks.
Design
Preclinical
Follow-up
10 weeks of treatment (after 20 weeks of disease induction)
Authors
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Hypothesis-generating for endothelin blockade in hypertensive nephropathy; leaves open translation to human disease.
Does bosentan reduce renal vascular fibrosis and improve survival in L-NAME-induced hypertensive mice?
Endothelin receptor antagonism with bosentan reverses renal vascular fibrosis and improves survival in a hypertensive mouse model, independent of blood pressure lowering.
Boffa et al. (2001) studied this question.
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