Key result
Intravenous Angiotensin II produced a rapid, threefold increase in collagen I gene activation in the aorta and renal cortex (P<0.01), requiring participation of endothelin and TGF-beta.
Population
Transgenic mice harboring the luciferase gene under the control of the collagen I-alpha 2 chain promoter
Comparison
Bolus intravenous administration of Angiotensin… vs Control
Design
Preclinical
Follow-up
up to 2 hours
Authors
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May implicate endothelin/TGF-beta pathways in Ang II fibrosis; extends animal models but leaves open human translation.
Effect estimate: 3-fold increase
p-value: p=< 0.01
Angiotensin II activates the collagen I gene in the aorta and renal cortex in vivo through mechanisms involving endothelin and TGF-beta, contributing to vascular fibrosis.
Fakhouri et al. (2001) studied Renal vascular fibrosis. Angiotensin II, Endothelin, TGF-beta vs. Control was evaluated on Collagen I gene activation in aorta and renal cortical slices (3-fold increase, p=< 0.01). Intravenous Angiotensin II produced a rapid, threefold increase in collagen I gene activation in the aorta and renal cortex (P<0.01), requiring participation of endothelin and TGF-beta.
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