Key result
Angiotensin II stimulates the expression of the alpha3(IV) collagen chain, but not alpha5(IV), in cultured murine proximal tubular cells, mediated in part by TGF-beta1 activation.
Angiotensin II stimulates the expression of the alpha3(IV) collagen chain in cultured murine proximal tubular cells, partly via TGF-beta1 activation.
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Hypothesis-generating in murine tubular cells; leaves open relevance to human renal fibrosis progression.
Wolf et al. (1999) studied this question. Angiotensin II was evaluated on mRNA and protein expression of alpha3 and alpha5(IV) collagen chains. Angiotensin II stimulates the expression of the alpha3(IV) collagen chain, but not alpha5(IV), in cultured murine proximal tubular cells, mediated in part by TGF-beta1 activation.
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