Population
Human arterial smooth muscle cells (SMCs)
Comparison
Angiotensin II vs Untreated cells / inactive homolog tyrphostin A1
Design
Preclinical
Authors
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Supports Ang II-TGF-beta pathway in vascular collagen synthesis; hypothesis-generating for fibrosis mechanisms, requires in vivo confirmation.
Angiotensin II stimulates collagen production in human arterial smooth muscle cells via the AT1 receptor and a TGF-beta autocrine loop requiring tyrosine phosphorylation.
Ford et al. (1999) studied this question.
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