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June 1, 1976Blood

Platelet inhibiton by sodium nitroprusside, a smooth muscle inhibitor

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Why the study?

Does sodium nitroprusside inhibit platelet aggregation and release?

Population

Platelet-rich plasmas (PRP) from normal controls and from patients receiving sodium nitroprusside

Comparison

Sodium nitroprusside vs Untreated platelets and baseline findings prior…

Design

Preclinical

Authors

ASA SaxonUCLA Medical CenterHKHE KattloveUCLA Medical Center

Discussion

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Implication

May support antiplatelet effects in nitroprusside-treated patients; hypothesis-generating and requires prospective human validation before practice change.

Structured PICO

Does sodium nitroprusside inhibit platelet aggregation and release?

P
Population
Platelet-rich plasmas (PRP) from normal controls and from patients receiving sodium nitroprusside
I
Intervention
Sodium nitroprusside (in vitro incubation for 3 min, and in vivo administration at 25 to 165 mug/min)
C
Comparator
Untreated platelets (in vitro) and baseline findings prior to administration of sodium nitroprusside (in vivo)
O
Outcome
Platelet aggregation in response to adenosine diphosphate (ADP), epinephrine, and collagensurrogate

Sodium nitroprusside acts as a platelet inhibitor, likely by inhibiting contractile proteins such as thrombosthenin, which may have implications for its use in cardiovascular patients.

Cite This Study

Saxon et al. (1976) studied this question.

synapsesocial.com/papers/6a89376a5c4c6b099dec627ahttps://doi.org/10.1182/blood.v47.6.957.957
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Release of a Platelet-Aggregating Substance (Adenosine Diphosphate) from Rabbit Blood Platelets Induced by Saline “Extract” of Tendons1963 · 181 citations
  2. 2Fine Structural Alterations Induced in Platelets by Adenosine Diphosphate1968 · 344 citations
  3. 3Effects of Sodium Nitroprusside and Other Pentacyanonitrosyl Complexes on Platelet Aggregation2009 · 13 citations
  4. 4Cardiovascular Actions of Sodium Nitroprusside in Animals and Hypertensive Patients1955 · 255 citations